The nicotinic acetylcholine receptor system is believed to be a part of memory and attention processes in the brain, and, thus, is thought to be dysregulated in memory- and attention-related disorders, including amnestic cognitive impairment, schizophrenia, attention-deficit disorder, and Alzheimer’s Disease. Therefore, nicotinic agonists, like nicotine, are potential treatment options for the memory and attention impairment components of many diseases. Nicotine has already shown significant improvement in memory- and attention-related symptoms and inhibition of impulsive responses in psychiatric populations.
To date, the reports of the benefits of nicotine have come from nonsmoking populations who have some form of cognitive impairment. The same effects of nicotine are not seen in current smokers, nor are they seen in healthy individuals without cognitive impairment. In fact, in adults with no memory or attention deficits, nicotine actually decreases performance on a battery of cognitive tests.
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